2015 Fiscal Year Final Research Report
Lard-based high-fat diet worsens liver injury but attenuates lung injury in endotoxemic rats
| Project/Area Number |
25450450
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Usami Makoto 神戸大学, 保健学研究科, 教授 (00193855)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 高脂肪食 / 敗血症 / トリブチリン |
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| Outline of Final Research Achievements |
Lard-based high-fat diet (HFD) feeding rats in endotoxemia worsened liver injury, but attenuated lung injury. HFD feeding enhanced proinflammatory lipid mediators 1.5 h after lipopolysaccharide injection suggesting relation to liver injury. The elevation of pulmonary secretory leukocyte protease inhibitor, anti-inflammatory protein, might be associated with the reduction of lung injury in these rats.
Tributyrin, prodrug of butyrate, suppressed endotoxin-induced lipid metabolism disorder. Oral tributyrin administration prevents elevation plasma triglyceride, total cholesterol and low-density lipoprotein cholesterol levels through improved fatty acid oxidation, PPARs and histone H3 in the liver in endotoxemic rats.
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| Free Research Field |
農学
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