2015 Fiscal Year Final Research Report
Differentiation mechanism of type ID myofiber as a ruminant-specific super fatigue-resistant myofiber type
Project/Area Number |
25450461
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrative animal science
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Research Institution | Tohoku University |
Principal Investigator |
WATANABE Kouichi 東北大学, (連合)農学研究科(研究院), 助教 (80261494)
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Co-Investigator(Kenkyū-buntansha) |
ASO Hisashi 東北大学, 大学院農学研究科, 教授 (50241625)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 超疲労耐久性筋線維 / ウシ / 3-ヒドロキシ酪酸脱水素酵素 / カルシウムイオン関連因子 / Sirtuin / カルニチンアシル基転移酵素ー1b / 機能適応 / ID型筋線維 |
Outline of Final Research Achievements |
Ruminant-specific type ID myofibers as a super fatigue-resistant myofiber, which are distributed in anti-gravity muscles involved in posture maintenance, possess strong 3-hydroxybutyrate dehydrogenase activity. In bovine muscles, our results suggest that type ID myofibers are possible to keep higher sarcoplasmic calcium ion level for long-term muscular movement, and have higher metabolic capacity of fatty acid than other myofiber types for sufficient energy supply. Moreover, it suggests that sirtuin1 activate PGC-1alpha for increasing of mitochondria in myofiber transition of "type IIB to type IIA" as oxidative change. Successively, upregulation of sirtuin3 in mitochondria seems to lead induction of fast-to-slow transformation and appearance of type ID myofiber involved in super fatigue-resistance.
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Free Research Field |
機能形態学
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