2015 Fiscal Year Final Research Report
Analysis of osmoreceptor molecules in the supraoptic nucleus of the hypothalamus
| Project/Area Number |
25450464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Naoki 鳥取大学, 農学部, 准教授 (80301951)
ASANO Atsushi 鹿児島大学, 共同獣医学部, 教授 (90312404)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 浸透圧受容 / バゾプレシン / 視索上核 / パッチクランプ / 細胞内Ca2+ / TRPV1 |
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| Outline of Final Research Achievements |
The regulatory mechanism for the body fluid osmolality is known to be precise and enable to control the large volume of the body water at a level of a few percent accuracy. The osmoreceptor is the molecule to sense changes in the body osmolality and the central osmoreceptor has not been elucidated to date. The purpose of the present study was to study the molecular identity of the central osmoreceptor. Our results suggest that the central osmoreceptor may be a heterotetramer comprised of the transient receptor potential vanilloid 1 (TRPV1) and its related molecules.
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| Free Research Field |
獣医生理学
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