The role and networks of immune and nonimmune cells in the small intestine in the early stage of gastrointestinal parasite infection.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrative animal science
• Research Institution: Miyagi University
• Principal Investigator: MORIMOTO Motoko 宮城大学, 食産業学部, 教授 (30250301)
• Co-Investigator(Renkei-kenkyūsha): TAKAI TOSHIYUKI 東北大学, 加齢医学研究所, 教授 (20187917)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 線虫 / 2型サイトカイン / 樹状細胞 / 小腸 / T細胞

Outline of Final Research Achievements

The coordinated actions of lymphocytes, innate immune cells, epithelium, and smooth muscles can play an important role in host intestinal immune function and homeostasis. We investigated type2 immune responses in early stage against nematode parasite in the murine intestine. The results suggested that innate immune cells initiate production of type2 cytokines, communicate with other immune cells including T cells and mediate adaptive pathogen-specific immune responses to eliminate pathogens. INFgamma; might regulate the termination of innate immune responses in the early stage. While, Th2 play mainly in memory responses against re-infection of nematode parasite.

Free Research Field

動物免疫学