Development of Unprecedented Catalytic Carbocyanation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Chiba University
• Principal Investigator: Arai Shigeru 千葉大学, 薬学研究科(研究院), 准教授 (20285224)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ニッケル / 遷移金属触媒 / シアノ化 / 環化 / アルキン / ヒドロシアノ化

Outline of Final Research Achievements

We have developed the discrimination of CC multiple bonds through Ni-catalyzed hydrocyanation and established regio- and stereoselective cyanation of alkynes, allenes, and enynes. These substrates are easily transformed to the corresponding carbonitriles and allene system is particularly effective to obtain a single product through this methodology. Allenyl cyclopropane are also effectively converted to the secondary carbonitriles as a sole product via CC sigma bond cleavage of cyclopropane and further application for the synthesis \of natural products are currently undergoing.

Free Research Field

有機合成化学