2015 Fiscal Year Final Research Report
Catalytic and Enantioselective Construction of Multi-Substituted Cyclohexane-Fused Heterocycles Having Chiral Tetrasubstituted Carbon
| Project/Area Number |
25460006
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
Harada Shinji 千葉大学, 薬学研究科(研究院), 助教 (10451759)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 合成化学 / 不斉触媒 / ヒドロカルバゾール / ホルミウム / 多環性骨格構築 / 全合成 / 不斉四級炭素 |
|---|
| Outline of Final Research Achievements |
I developed the catalytic and enantioselective Diels-Alder reaction using heterocycle-fused siloxydienes. This reaction was promoted by novel chiral holmium catalyst. The adducts are optically active multi-cyclic compounds, and they could be used as synthetic intermediates of biologically active compounds. For instance, I achieved the enantioselective total synthesis of Minovincine from the optically active hydrocarbazole derived from the Diels-Alder reaction of indole-fused diene.
|
| Free Research Field |
有機合成化学
|
