Development of the stereocontrolled synthesis of the highly oxygenated steroids

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: Urabe Daisuke 東京大学, 薬学研究科(研究院), 講師 (80503515)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 有機合成化学 / 天然物 / 生物活性物質 / 全合成 / 立体選択性 / ステロイド

Outline of Final Research Achievements

In this research project, we have established the strategy for the divergent synthesis of the highly oxygenated steroid compounds. The stereocontrolled synthesis of the core system of the steroid has been developed by the convergent radical coupling of the diverse AB-rings and the D-ring and the following stereoselective intramolecular aldol reaction. Based on the developed method, the total synthesis of complex natural product ouabagenin has been achieved. Furthermore, the intermediate towards toosendanine has been synthesized.

Free Research Field

有機合成化学