2016 Fiscal Year Final Research Report
Novel synthesis of nitrogen containing heterocycles using rearrangement reactions of haloamines
Project/Area Number |
25460014
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Osaka University |
Principal Investigator |
Murai Kenichi 大阪大学, 薬学研究科, 助教 (70532068)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 複素環化学 / 転位反応 / 酸化反応 / ハロアミン |
Outline of Final Research Achievements |
The development of an efficient synthetic method for nitrogen-containing heterocyclic compounds is highly important, because they are contained in a large number of biologically active compounds. In this research, we conducted the study on the rearrangement reaction of haloamines (nitrogen-halogen compounds), an electrophilic nitrogen source, to develop a new synthesis method for nitrogen-containing compounds. As a results, we have found that the rearrangement reactions of haloamines having electron-donating groups such as a nitrogen atom, an oxygen atom, and aromatic substituents occur efficiently and shown their usefulness for the heterocyclic synthesis.
|
Free Research Field |
有機合成化学
|