Novel synthesis of nitrogen containing heterocycles using rearrangement reactions of haloamines

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460014
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Osaka University
• Principal Investigator: Murai Kenichi 大阪大学, 薬学研究科, 助教 (70532068)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 複素環化学 / 転位反応 / 酸化反応 / ハロアミン

Outline of Final Research Achievements

The development of an efficient synthetic method for nitrogen-containing heterocyclic compounds is highly important, because they are contained in a large number of biologically active compounds. In this research, we conducted the study on the rearrangement reaction of haloamines (nitrogen-halogen compounds), an electrophilic nitrogen source, to develop a new synthesis method for nitrogen-containing compounds. As a results, we have found that the rearrangement reactions of haloamines having electron-donating groups such as a nitrogen atom, an oxygen atom, and aromatic substituents occur efficiently and shown their usefulness for the heterocyclic synthesis.

Free Research Field

有機合成化学