2015 Fiscal Year Final Research Report
Synthetic Study of Tirandamycins
| Project/Area Number |
25460017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Toho University (2014-2015)
Nagasaki University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 全合成 / フィラリア / チランダマイシン |
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| Outline of Final Research Achievements |
Lymphatic filariasis, also known as elephantiasis, is caused by the parasitic nematodes and represents a worldwide health crisis. In this study, we investigated synthetic study of tirandamycin B which efficiently kills the parasite. Continuous stereo centers of tirandamycin B were constructed by Marshall method employing chiral allenylznic spices and addition of lithio furan. After construction of the bicyclic core through Achmatowicz reaction, Witting reaction gave us the key intermediate of tirandamycin B.
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| Free Research Field |
有機化学
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