2015 Fiscal Year Final Research Report
A novel strategy for benzylation and C-H activation by the (eta3-benzyl)palladium(II) system in water.
| Project/Area Number |
25460026
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | パラジウム / ベンジル化 / ベンジルアルコール / 水 / 環境負荷低減型 |
|---|
| Outline of Final Research Achievements |
A unique strategy for benzylation and C-H activation by the (η3-benzyl)palladium(II) system from a water-soluble palladium(0)/sodium diphenylphosphinobenzene-3-sulfonate (TPPMS) catalyst and benzyl alcohol in water is developed. Notably, water may activate the sp3 C-O bond, then stabilize the Pd(II) cation species by hydration, which can then undergo innovative direct transformation reactions. N-Benzylation/benzylic C-H activation cascade is devised as a novel and efficient synthetic route for N-(1,2-diphenylethyl)anilines or 3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine-1,1-dioxides. A direct catalytic substitution of benzylic alcohols, which affords the desired products along with water as the sole co-product, is an efficient and environmentally benign method.
|
| Free Research Field |
有機化学
|
