Design of supramolecular complexes to form asymmetry nanotube structure and the application for controlled release carrier

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460032
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Chiba University
• Principal Investigator: Yamamoto Keiji 千葉大学, 薬学研究科(研究院), 名誉教授 (50110341)
• Co-Investigator(Kenkyū-buntansha): MORIBE Kunikazu 千葉大学, 大学院薬学研究院, 教授 (50266350) ; HIGASHI Kenjirou 千葉大学, 大学院薬学研究院, 講師 (40451760)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 分子製剤学 / 有機ナノチューブ / シクロデキストリン / 分子状態 / 薬物溶解性 / 放出制御 / 固体NMR / 難水溶性薬物

Outline of Final Research Achievements

In this study, the relationships between molecular state and dissolution character of guest drug in host materials (organic nanotube and cyclodextrin-polypseudorotaxane) were clarified. The encapsulation ratio and dissolution of guest drug can be controlled by changing the character of host materials. The knowledge obtained in this study will be a help on promoting the application of host materials in pharmaceutical sciences. In the future, new controlled release carriers tailored to therapeutic drug and therapeutic purpose are expected to be developed.

Free Research Field

物理薬剤学