Physicochemical study on molecular design of a fluorescent probe responding to internal potentials

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460039
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Gifu Pharmaceutical University
• Principal Investigator: Uno Bunji 岐阜薬科大学, 薬学部, 教授 (80160307)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 蛍光プローブ / 電位応答 / 光誘起電子移動 / 分子内電子移動 / フェロセン / ダンシル基 / プロトン移動共役電子移動 / オルトカルボラン

Outline of Final Research Achievements

Molecular design of a fluorescent probe responding to internal potentials, useful for innovative drug development against cancer, is discussed from the point of view of function of the crosslinked structure between fluorescent and response groups in the probe. It has been found that efficient photo-induced electron transfer occurs in the crosslinking of a short methylene chain and is inhibited by intermolecular electron transfer in the conjugated crosslinking. In addition, hydroquinone and catechol as well as ferrocene were found to be the good candidates for response groups to internal potential. On the other hand, o-carborane is likely to be the new fluorescent groups in the probes.

Free Research Field

物理系薬学　有機電子移動化学