Design of polymeric nanoparticle for treatment of periodontal disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Aichi Gakuin University
• Principal Investigator: Yamamoto Hiromitsu 愛知学院大学, 薬学部, 教授 (30275094)
• Co-Investigator(Kenkyū-buntansha): MITSUO FUKUDA 愛知学院大学, 歯学部, 教授 (40156790) ; TADAHIDE FURUNO 愛知学院大学, 薬学部, 教授 (80254308)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 高分子ナノ粒子 / 歯周病 / 歯周組織浸透性 / バイオフィルム感染症 / ドラッグデリバリーシステム / 高分子ミセル

Outline of Final Research Achievements

Polymeric nanoparticle and polymeric micelles were designed as drug carrier for treatment of periodontal disease. In this study, we established evaluation method of in vitro anti-inflammatory effect with macrophage cell under cocultivation with P. gingivalis. Nanocarriers shows strongly suppression of cytokine production compared with drug solution. Furthermore, deeply penetration of nanocarriers into the periodontal tissue were observed with the confocal laser scanning microscopy. Nanocarrier indicated the strongly anti-bacterial effect by biofilm retraction effect. We could successfully prepare the nano drug carrier for treatment of periodontal disease.

Free Research Field

製剤工学