Determination of intra-cellular dynamics of platinum(IV) complexes using imaging technique

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460047
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Suzuka University of Medical Science (2015); Meijo University (2013-2014)
• Principal Investigator: Kojima Nakao 鈴鹿医療科学大学, 医用工学部, その他 (80333178)
• Co-Investigator(Kenkyū-buntansha): UEDA Koji 名城大学, 薬学部, 助教 (30351092) ; OKAMOTO Yoshinori 名城大学, 薬学部, 助教 (50512323)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 白金４価錯体 / 活性酸素種 / 酸化ストレス / グルタチオン / 薬物耐性 / タイムラプス解析 / ヒト卵巣がん

Outline of Final Research Achievements

Platinum(IV) [Pt(IV)] complexes are one of the attractive next-generation anticancer drugs. Beside Pt(II)-based drugs such as cisplatin, carboplatin, and oxaliplatin, Pt(IV) complexes show less adverse effects and can be administrated orally. In addition, because Pt(IV) complexes adopt octahedral coordination geometry, it also have an advantage that can be coordinated with more functional ligands than Pt(II) complexes. These different features prompted us to investigate the effectiveness of Pt(IV) complexes on cisplatin-resistant cancer cells with its mechanisms. This study aims to elucidate the anti-cancer effects of Pt(IV) complexes.

Free Research Field

衛生薬学