2015 Fiscal Year Final Research Report
Exploratory research of high activity metal complexes by organic and inorganic nano-composite with anti-diabetic effect
| Project/Area Number |
25460048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kobe Women's University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAKUTA Hiroki 岡山大学, 大学院医歯薬学総合研究科, 准教授 (80362961)
NAITO Yuki 京都薬科大学, 助手 (80610120)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 金属錯体 / 無機医薬品 / 糖尿病 / 生活習慣病 / 天然物 |
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| Outline of Final Research Achievements |
In this study, we synthesized various metal complexes with organic compounds, medicine, and natural products. Above the results, we suggested that the metal complex with the high anti-diabetic effect was Zn complex with ZnS2O2 or ZnSe2O2 coordination mode. These complexes showed the blood glucose normalizing, anti-insulin resistance, and glucose tolerance improved effects by using type 2 diabetes mellitus model KKAy or obob mice. Moreover, Zn complexes activates the insulin signaling pathway with inducing Akt phosphorylation by a insulin-independent manner. It is suggested that this signal activation of Zn complexes in insulin signaling pathway has the potent to ameliorate the insulin resistance in the peripheral tissues; such as muscles and adipose. And it is expectable that this would be the novel mechanism for the treatment of DM.
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| Free Research Field |
生物無機化学
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