2017 Fiscal Year Final Research Report
Development of traceable photosensitizer to produce enough effect of photodynamic therapy
| Project/Area Number |
25460053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAZAKI Shoko 崇城大学, 薬学部, 講師 (40435152)
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Keywords | MRI / デキストラン / クロリンe6 / 腫瘍 / 光線力学療法 / 体内動態 |
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| Outline of Final Research Achievements |
Gadolinium chelate-conjugated dextran (Gd-Dex) was synthesized as a carrier to trace photosensitizer for photodynamic therapy of tumor. Gd-Dex accumulated in a tumor immediately after intravenous injection to a S180 tumor model mouse, whereas it remained in a blood compartment of healthy mouse for more than 60 min. Amount of Gd-Dex accumulation per tumor volume was almost constant in a tumor size 500-3000 mm3 60 min after its intravenous administration. Although Gd-Dex circulated in the blood was excreted from the kidney after receiving hydrolysis, some of Gd-Dex accumulated in the liver. On the other hand, photosensitizer-conjugated dextran was successfully synthesized by the reaction of ethylenediamine-derived chlorin e6 and cyano-derrivatives of dextran. These results are important data for MRI-guided photodynamic therapy of tumor.
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| Free Research Field |
物理系薬学
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