2016 Fiscal Year Final Research Report
Highly efficient and sensitive analysis of multiplex drug metabolism reactions
Project/Area Number |
25460055
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Physical pharmacy
|
Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
Mie Yasuhiro 国立研究開発法人産業技術総合研究所, 生物プロセス研究部門, 主任研究員 (00415746)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 電気化学分析 / 薬物代謝 / ナノ構造 |
Outline of Final Research Achievements |
Highly efficient assay of drug metabolism reaction with drug metabolism enzyme such as cytochrome P450 is very important to develop drug discovery and well-personalized drug administration. However, the current assay system is time-consuming and low sensitive. Hence, the rapid and sensitive technique is desired to achieve more efficient assay systems for drug metabolism reactions, and an electrochemical method to drive and detect the enzyme reaction simultaneously is promising. In the present study, we found the effective electrode surface in terms of both chemical and physical senses to immobilize and drive the corresponding enzymes, and to detect the drug metabolism reaction.
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Free Research Field |
電気化学
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