2015 Fiscal Year Final Research Report
The role of TYK2 in the modulation of inflammatory responses
| Project/Area Number |
25460056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
MUROMOTO Ryuta 北海道大学, 薬学研究科(研究院), 助教 (30455597)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | TYK2 / 炎症 / サイトカイン / 乾癬 |
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| Outline of Final Research Achievements |
We aimed to investigate the role of Tyrosine kinase 2 (TYK2) in the modulation of inflammatory responses. We have found that TYK2 is involved in maintaining the basal expression of chemokine mRNAs in macrophages and in IL-17A-induced activation of keratinocytes. These findings suggest that TYK2 inhibition may be useful as a therapeutic strategy for treating immune-mediated inflammatory diseases such as psoriasis.
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| Free Research Field |
生物系薬学
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