Molecular mechanisms of presynaptic assembly in serotonergic neurons HSN in C. elegans

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460058
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: TARU Hidenori 北海道大学, 薬学研究院, 准教授 (30533731)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 神経細胞 / シナプス / セロトニン作動性

Outline of Final Research Achievements

At presynaptic structures in neurons, Cytomatrix at the Active Zone (CAZ)”, a group of unique adapter proteins, assembles and organizes functional molecules specialized for synaptic transmission. This project addressed the molecular mechanisms of presynaptic assembly mainly in serotonergic neurons HSN in nematode C. elegans: SYD-1, a key regulator of presynaptic assembly, negatively regulates GTPase through the binding of RhoGAP-like domain; RIMB-1, previously uncharacterized CAZ protein, regulates the localization of voltage-gated calcium channels at presynaptic structures.

Free Research Field

医歯薬学