2015 Fiscal Year Final Research Report
Activation mechanism of unfolded protein response by membrane lipid saturation
| Project/Area Number |
25460060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kono Nozomu 東京大学, 薬学研究科(研究院), 講師 (50451852)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | リン脂質 / 脂肪酸 / 小胞体ストレス応答 |
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| Outline of Final Research Achievements |
Increased levels of saturated fatty acids in membrane phospholipids (membrane lipid saturation) activated IRE1α and PERK, but did not activate ATF6α. A conventional ER stressor induced clustering of fluorescently tagged IRE1α fusion protein, but membrane lipid saturation did not. These results suggest membrane lipid saturation and unfolded proteins activate the UPR through different mechanisms. Analysis of an ER membrane protein involved in the UPR activation upon membrane lipid saturation revealed a homeostatic mechanism against membrane lipid saturation.
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| Free Research Field |
脂質生物学
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