2015 Fiscal Year Final Research Report
Molecular action mechanisms of chemical compounds that induce non-proteasomal degradation of beta-catenin
| Project/Area Number |
25460069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAWANO Tomikazu 岩手医科大学, 薬学部, 教授 (30283807)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | がん / シグナル伝達 / 分子標的薬 |
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| Outline of Final Research Achievements |
Abnormal activation of the Wnt/beta-catenin pathway observed in malignant tumors has been an attractive target pathway for anticancer therapeutics. In the present study, we studied action mechanism of IMU14 derivatives that we identified as inhibitors of Wnt/beta-catenin pathway. We hypothesized that IMU compounds switch proteasomal beta-catenin degradation to lysosomal proteoyisis, and verified the hypothesis. In addition to in vitro studies, antitumor activity of an IMU compound was analyzed in a dextran sulfate-induced colorectal tumor model in APCMin/+ mice.
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| Free Research Field |
生物系薬学
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