2015 Fiscal Year Final Research Report
The roles of uPA/uPAR on the inflammatory osteoclastogenesis
| Project/Area Number |
25460078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
KANNO YOSUKE 同志社女子大学, 薬学部, 助教 (40416178)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | uPAR / uPA / LPS / osteoclast / bone |
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| Outline of Final Research Achievements |
The aim of this study was to clarify the role of uPA/uPAR on the inflammatory bone loss. We found that uPA attenuated inflammatory osteoclastogenesis through the activation of AMPK. Additionally, we found that uPAR regulated inflammatory osteoclastogenesis through the integrin/Akt pathway. Moreover, we found that uPAR regulated inflammation-induced TNF-α production. These data suggest that uPA/uPAR plays an important roles on the inflammatory bone loss.
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| Free Research Field |
細胞生物学
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