2015 Fiscal Year Final Research Report
Function and its regulatory mechanism of Elovl3 in obesity
| Project/Area Number |
25460079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
Fujimori Ko 大阪薬科大学, 薬学部, 准教授 (70425453)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 極長鎖脂肪酸 / 肥満 |
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| Outline of Final Research Achievements |
Many factors are involved in the regulation of obesity. PPARγ, a nuclear receptor plays a central role in the regulation of obesity. We identified that the expression of the Elovl3 (Elongation of very long chain fatty acid) gene was activated by PPARγ in adipocytes, and the enzymatic products of Elovl3, C18:1 and C20:1 fatty acids bind with PPARγ as ligands. We also constructed mouse Elovl3 antibody, and used for analysis. Moreover, the Elovl3 KO mice are constructing.
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| Free Research Field |
生化学
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