Analysis of the mechanism for the cardiomyogenic effect of AW551984 on pluripotent stem cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460083
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: National Institute of Health Sciences
• Principal Investigator: Yasuda Satoshi 国立医薬品食品衛生研究所, 再生・細胞医療製品部, 室長 (20381262)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 多能性幹細胞 / 心筋分化

Outline of Final Research Achievements

To repair functions of the injured heart, a great deal of research has attempted to develop regenerative medicine using pluripotent stem cell–based cardiomyocytes as cell therapy products. Although several cell signals have been reported to play important roles in cardiac differentiation, its detailed molecular mechanism remains unknown. We have previously showed AW551984 as a regulator of cardiomyogenesis, and here identified AW551984-binding proteins (AW551984-BPs), which expressed in embryoid bodies of mouse embryonic stem (ES) cells. We further extracted several AW551984-BPs involved in regulation of cardiomyogenesis in mouse ES cells. We also indicated that human homolog VWA5A modulated in vitro cardiac differentiation of human iPS cells.

Free Research Field

再生医療