2015 Fiscal Year Final Research Report
The defensive role of immature myeloid cells in severe invasive group A streptococcal infections
| Project/Area Number |
25460085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 劇症型溶血性レンサ球菌感染症 / IFN-γ / IL-6 |
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| Outline of Final Research Achievements |
Group A Streptococcus (GAS) infections range from mild symptoms, such as skin infections, to serious infections including toxic shock syndrome. Neutrophils and myeloid cells are important in protecting against GAS infections. However, during severe invasive GAS infections that accompanied with neutropenia, it had been unclear which factors are protective against such infections, and which cell population is the source of them. Here we show that mice infected with severe invasive GAS isolate exhibit excessive levels of plasma interferon (IFN)-g and interleukin (IL)-6. Interestingly, immature myeloid cells (IMCs) are the source of IFN-g and IL-6 in mice infected with severe invasive GAS isolates. Adoptive transfer of IMCs is successful to improve bacterial clearance and survival rate of mice infected with severe invasive GAS isolate. Our results indicate that IMCs have a defensive role in severe invasive GAS infections.
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| Free Research Field |
医歯薬学
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