2015 Fiscal Year Final Research Report
Effect of nicotine on reward-based decision-making in healthy and methamphetamine-treated rat
| Project/Area Number |
25460094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Kiyofumi 名古屋大学, 医学部附属病院, 教授 (30303639)
YAMANAKA Akihiro 名古屋大学, 環境医学研究所, 教授 (60323292)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 意思決定 / ニコチン / 覚せい剤 / ニコチン受容体 |
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| Outline of Final Research Achievements |
In this study, we examined the effects of nicotine on reward-based decision-making in healthy and methamphetamine (METH)-treated rat. We analyzed the performance of rats in a gambling test for rodents. Nicotine treatment (0.3 mg/kg) ameliorated the abnormal arm-choice behavior of METH-treated rats in the gambling test. However, chronic nicotine treatment (0.3 or 0.6 mg/kg) did not show changes in arm-choice behavior in healthy rats. Our findings suggest that nicotine may have some therapeutic effects against impairment of decision-making in METH addicts.
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| Free Research Field |
薬理系薬学
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