2015 Fiscal Year Final Research Report
Role of integrin alpha5beta1 in dopaminergic innervation of striatal neurons.
| Project/Area Number |
25460095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
Izumi Yasuhiko 京都大学, 薬学研究科(研究院), 助教 (60456837)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ドパミンニューロン / インテグリン / 神経突起伸長 / パーキンソン病 |
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| Outline of Final Research Achievements |
The mechanisms by which dopaminergic axons from the substantia nigra extend to the striatum in developmental processes remains to be known. Using knockdown and overexpression experiments, we demonstrated that integrin α5β1, one of cell adhesion molecules, played a role in the process of dopaminergic innervation of striatal neurons. We expect that integrin α5-overexpressing dopaminergic neurons grafted into the striatum will effectively innervate the striatal neurons in the transplantation therapy for Parkinson disease.
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| Free Research Field |
神経薬理学
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