2015 Fiscal Year Final Research Report
Analysis and modeling of the effect of microenvironment on tumor growth.
| Project/Area Number |
25460097
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
SAITO Sakae 東北大学, 東北メディカル・メガバンク機構, 講師 (20335491)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAYAMA Katsuya 九州工業大学, 大学院情報工学研究院, 准教授 (70363398)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 癌 / ストレス |
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| Outline of Final Research Achievements |
Tumor microenvironment is composed of non-cancer cells, such as vascular endothelial cells and immune cells, which are exposed to hypoxic and nutritional stress in tumor. The cellular stress response plays an important role in cell survival under stress conditions and results in tumor progression. To show the impact of microenvironment on tumor growth and morphology, we disclosed the intra-tumor heterogeneity by single cell analysis, and presented a numerical model for tumor growth and angiogenesis.
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| Free Research Field |
分子生物学
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