Elucidation of the treatment against metabolic syndrome by regulating endoplasmic reticulum function

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460101
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Hiroshima University
• Principal Investigator: Hosoi Toru 広島大学, 医歯薬保健学研究院(薬), 准教授 (40379889)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: レプチン

Outline of Final Research Achievements

Obesity is associated with metabolic syndrome such as hypertension, diabetes, and hyperlipidemia. In the present study, we analyzed the mechanisms and pharmacological treatment against obesity focusing on leptin resistance, which is known to be involved in the pathophysiology of obesity. We found that glial cells may be involved in the leptin signaling in neuronal cells. Furthermore, we found novel mechanisms of leptin resistance caused by ER stress and other factors. These results would be useful information for elucidating strategy for the treatment of metabolic syndrome.

Free Research Field

薬理学