2015 Fiscal Year Final Research Report
Elucidation of pathogenesis of psoriasis using TRAF3IP/2Act 1 deficient mice and development of new therapy
| Project/Area Number |
25460107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Nihon Pharmaceutical University |
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Principal Investigator |
Tishio Inoue 日本薬科大学, 薬学部, 准教授 (70458610)
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| Co-Investigator(Kenkyū-buntansha) |
Uramaru Naoto 日本薬科大学, 薬学部, 講師 (90424069)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 乾癬 / Traf3ip2/Act1 / JAK/STAT |
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| Outline of Final Research Achievements |
The goal of this study was to explore the mechanisms involved in the pathogenesis of psoriasis using Traf3ip2/Act1 deficient mice. The result suggested that the Traf3ip2/Act1 protein plays an important role in pathogenesis of psoriasis, and were considered can be a new model mice for psoriasis. Moreover, JAK/STAT signaling could be considered as potential therapeutic targets in ameliorating psoriasis.
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| Free Research Field |
薬理学
|
