2015 Fiscal Year Final Research Report
Study of oxydative stress sensor DJ-1 for therapeutic target of neurodegenerative diseases
| Project/Area Number |
25460109
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Ritsumeikan University (2015)
Kyoto Pharmaceutical University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | DJ-1タンパク質 / DJ-1結合化合物 / パーキンソン病 / アルツハイマー病 / 神経変性疾患 / 抗酸化作用 / ニコチン受容体 |
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| Outline of Final Research Achievements |
Oxidative stress is one of the causes of neurodegenerative diseases, such as Parkinson's (PD) and Alzheimer's diseases (AD). Since symptomatic disease therapies are used, identification of compounds or proteins that inhibit oxidative stress-induced neuronal cell death is necessary. DJ-1 is a causative gene product of familial PD and plays a role in anti-oxidative stress reaction. Recently, we have identified some DJ-1-binding compounds. In this study, wild-type and DJ-1-knockout mice were injected intraperitoneally with DJ-1-binding compounds in the presence or absencs of neurotoxin MPTP. This research showed that DJ-1-binding compounds inhibited MPTP-induced reduction of retention time on the rotor rod bar, neuronal cell death in the substantia nigra and striatum and dopamine content in wild-type mice but not in DJ-1-knockout mice. From these results suggest that DJ-1 is one of novel therapeutic molecular targets for neurodegenerative diseases.
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| Free Research Field |
神経薬理学
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