Understanding for the pathogenic mechanisms of NOX1 expressed in macrophages in intestinal inflammation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460110
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: Kato Shinichi 京都薬科大学, 薬学部, 教授 (90281500)
• Co-Investigator(Kenkyū-buntansha): IWATA Kazumi 京都府立医科大学, 医学(系)研究科(研究院), 講師 (60305571)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: NOX1 / 活性酸素 / マクロファージ / 消化管炎症 / サイトカイン / ケモカイン

Outline of Final Research Achievements

The aim of the present study is to clarify the pathogenic role of NOX1 in colonic inflammation. We showed that 1) NOX1 plays detrimental roles in the pathogenesis of TNBS-induced colitis accompanied by various inflammatory responses; 2) NOX1 is expressed in macrophages located in lamina propria of colon; 3) NOX1 expressed in macrophages regulates the expression of cytokines and chemokine in response to inflammatory stimuli. These findings suggest that NOX1 expressed in colonic macrophages is involved in the pathogenesis of colonic inflammation via up-regulation of inflammatory cytokines and chemokines.

Free Research Field

消化器・炎症薬理