2015 Fiscal Year Final Research Report
Semaphorin 7A plays a critical role in airway inflammation
| Project/Area Number |
25460112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | セマフォリン / 喘息 |
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| Outline of Final Research Achievements |
Elevated allergen-specific IgE levels are a hallmark of allergic asthma, a disease involving chronic airway inflammation characterized by airway hyperresponsiveness (AHR); neutrophilic airway inflammation is found in patients with severe asthma. Meanwhile, semaphorins regulating neuronal and immune function have been focused on in several diseases. Here, we investigated whether semaphorin 7A (SEMA7A) is related to IgE-mediated neutrophilic inflammation in mice. Our results highlight the importance of SEMA7A for neutrophilic airway inflammation, which is related to the development of AHR, in IgE-sensitized mice, indicating critical steps of leukocyte infiltration in vivo. The efficacy of functional blockage of SEMA7A may offer a new therapeutic approach in the treatment of severe and/or chronic allergic asthma associated with neutrophilic airway inflammation.
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| Free Research Field |
免疫薬理学
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