Lb. reuteri BM53-1 inhibits the S. mutans biofilm formation through the alteration of gene expressions

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460121
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Natural medicines
• Research Institution: Hiroshima University
• Principal Investigator: NODA MASAFUMI 広島大学, 医歯薬保健学研究院 (薬), 特任講師 (40457289)
• Co-Investigator(Kenkyū-buntansha): SUGIYAMA Masanori 広島大学, 大学院医歯薬保健学研究院, 教授 (30106801)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: プロバイオティクス / 乳酸菌 / S. mutans / バイオフィルム

Outline of Final Research Achievements

We previously isolated the plant-derived lactic acid bacterium (LAB) strain, designated BM53-1, from catmint (Actinidia polygama) and identified it as Lactobacillus reuteri. The one of the caries causative bacterium Streptococcus mutans forms biofilm, and the BM53-1 strain produces anti biofilm-forming activity compound in culture broth. In the present study, it was found that the anti biofilm compound alternates the gene expression balances of gtf genes, which are necessary to biofilm formation, by using the quantitative PCR method.

Free Research Field

分子微生物学