Synthesis and functional research of glycosphingolipids from marine natural products

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Natural medicines
• Research Institution: Keio University
• Principal Investigator: Hada Noriyasu 慶應義塾大学, 薬学部, 准教授 (70296531)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 糖脂質 / 海綿 / 化学合成 / 生物活性 / ホヤ

Outline of Final Research Achievements

The oligosaccharide residues of glycoprotein and glycosphingolipids in mammalian tissues have been extensively studied for various biological recognition in recent years. In contrast, much less time has been devoted to structures of oligosaccharides from invertebrates that differ significantly from mammalian glycans. Due to these differences in the glycan structure we have been interested in the relationships between the structure and biological activity of oligosaccharides from invertebrate species, and in our continuing studies to elucidate the mechanism of host-parasite interaction. We carried out the synthesis of oligosaccharides from some Marine sponge and Sea‐squirts, and got target oligosaccharides and elucidated a biological activities.

Free Research Field

糖化学　天然物化学