2015 Fiscal Year Final Research Report
The search and functional analysis of the natural compound promoting the differentiation of regulatory T cells.
| Project/Area Number |
25460132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Musashino University |
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Principal Investigator |
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| Research Collaborator |
INOUE Makoto 愛知学院大学, 薬学部, 教授 (50191888)
YOSHIMURA Akihiko 慶應義塾大学, 医学部, 教授 (90182815)
TANABE Hiroki 北陸大学, 薬学部, 准教授 (10415606)
KATAKAWA Kazuaki 武蔵野大学, 薬学部, 講師 (90433606)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 制御性T細胞 / 免疫賦活 / 生薬 / 天然物 / 沈香 / 癌 / インターフェロンガンマ / 自己免疫疾患 |
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| Outline of Final Research Achievements |
In this study, I searched for the natural compound which regulated the differentiation of the regulatory T cell which controlled excessive immunity. As a result, I found that the ingredient included in the crude drug called JINKO inhibited the differentiation of the regulatory T cells from Naive T cells. This natural compound can activate immunity by restraining the differentiation of the regulatory T cells, and anti-tumor activity is expected.
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| Free Research Field |
天然物化学
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