Development of artificial EGF receptor-ligand system based on coiled-coil peptides to manipulate cell functions

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Osaka Prefecture University
• Principal Investigator: Nakase Ikuhiko 大阪府立大学, 21世紀科学研究機構, 講師 (40432322)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 人工受容体 / 細胞機能制御 / ヘリックス相互作用 / ペプチド認識

Outline of Final Research Achievements

To develop artificial receptor-ligand system by usage of artificial coiled-coil peptides to induce receptor dimerization and activation is purpose of research. In this research, artificial epidermal growth factor receptor-ligand system as a model was created to control receptor-based cellular functions. As results, helix peptide ligands effectively activate the artificial receptor on cellular membranes, and the peptide ligand-modified cellular vesicles that can also activate the objective receptor could be successfully developed.

Free Research Field

細胞ペプチド化学