Research on IDO inhibitor as anticancer agent

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Kogakuin University (2015); Okayama University (2013-2014)
• Principal Investigator: MATSUNO KENJI 工学院大学, 先進工学部, 教授 (50433214)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: リード化合物 / 抗がん剤 / がん免疫療法剤 / IDO / 免疫寛容 / 構造活性相関

Outline of Final Research Achievements

The design, synthesis and biological evaluations for our original IDO inhibitors were conducted. We succeeded enhancement of IDO enzyme inhibition, as well as cellular IDO inhibition. As the result of our efforts, many potent analogues were identified. Furthermore, all potent IDO inhibitors demonstrated in vivo efficacy. The activity would be attributed to IDO inhibition since inactive IDO inhibitor did NOT show the in vivo activity.

Free Research Field

医薬化学