2015 Fiscal Year Final Research Report
Utilization of anti-inflammatory/anti-oxidative/phagocytic activities by type 2 microglia for an Alzheimer's disease therapy
| Project/Area Number |
25460150
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Nigata University of Phermacy and Applied Life Sciences (2014-2015)
Kumamoto University (2013) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | アルツハイマー病 / 記憶改善 / ミクログリア / レチノイド / Am80 / HX630 / ペプチド / 9F5 |
|---|
| Outline of Final Research Achievements |
In this study, we focused on retinoid as a compound to promote the anti-inflammatory, anti-oxidative, and phagocytic activities of type 2 microglia. Oral co-administration of Am80 (0.5 mg/kg) and HX630 (5 mg/kg) for 17 days significantly improved memory deficits (Morris water maze) in 8.5-month old APP23 mice. A heptapeptide Sx markedly induced the expression of heme oxygenase-1 in mouse microglia. The antigen molecule for 9F5, a monoclonal antibody that recognizes inflammatory type (type 1) of rat microglia, was identified, and the GFP knock-in mouse was also developed.
|
| Free Research Field |
神経化学
|
