2015 Fiscal Year Final Research Report
Estimation of fetotoxicity of chemical compounds with human fetal liver cells and molecular basis of their toxicities
| Project/Area Number |
25460167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Shinshu University |
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Principal Investigator |
YAMAORI Satoshi 信州大学, 学術研究院医学系(医学部附属病院), 准教授 (40360218)
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| Co-Investigator(Kenkyū-buntansha) |
OHMORI Shigeru 信州大学, 学術研究院医学系(医学部附属病院), 教授 (70169069)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ヒト胎児肝細胞 / 胎児毒性 / 薬物代謝酵素 |
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| Outline of Final Research Achievements |
Fetotoxicity of chemical compounds was investigated with human fetal liver cells. Among the chemical compounds examined, tamoxifen, diclofenac, and retinoic acid induced strong cytotoxicity, from which glutathione S-transferase did not protect human fetal liver cells. A lot of test compounds induced the expression of drug-metabolizing enzymes such as cytochrome P450s and sulfotransferases in human fetal liver cells.
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| Free Research Field |
薬物代謝学、衛生化学
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