2016 Fiscal Year Final Research Report
Effects of early life stress on brain function and preventive effect by auditory enrichment
| Project/Area Number |
25460168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 母仔隔離 / 脳機能 / 自然環境音 / ストレス / 行動試験 / 超音波発声 |
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| Outline of Final Research Achievements |
Neonatal Wistar rats were isolated from their mother and also siblings in a soundproof chamber for 4 hours a day during post-natal day (PND) 2 to 9 or 3 to 10. In the auditory enrichment group, natural sounds were played back at 45 - 55 dB during maternal isolation. Unfortunately, Wistar rats were not suitable for Marble-burying test. No significant differences were observed between control and isolation groups in Hole-board test (done at PND30), blood corticosterone level (measured at PND9) and mRNA level of GABAb receptor in ventral Hippocampal CA1 area (measured at PND9). Climbing behavior was significantly increased while urinary frequency was significantly decreased in auditory enrichment group. During maternal isolation, ultra-sonic vocalization (USV) was increased and it was reduced in auditory enrichment group. USV was also increased in resident-intruder test (recorded at post-natal month 3 and 6), but it was not affected by maternal isolation.
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| Free Research Field |
薬学
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