Analysis of cytotoxicity to host cells of live bacilli among Mycobacterium species

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460170
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental and hygienic pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: Takii Takemasa 名古屋市立大学, 薬学研究科(研究院), 准教授 (80244573)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 感染症 / 結核菌 / 細胞傷害性 / サイトカイン / 抗酸化活性

Outline of Final Research Achievements

We have previously reported that virulent Mycobacteria exhibit strong cytotoxicity to host cells (JICR, 2001). Supported by this research fund, we revealed that the anti-oxidative activity of those bacilli would relate to the long time survival in the host cells and the strong activity of cytokines production from infected host cells (Kekkaku, 2015, Microbiol Immunol., 2015). So, we expected that the anti-oxidative activity of the bacilli would relate to the cytotoxicity to the host cells.

Free Research Field

微生物免疫学