Effects of amorphous nanoparticles on allergic ashtma and autoimmune diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460180
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental and hygienic pharmacy
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: Yoshino Shin 神戸薬科大学, 薬学部, 教授 (00260729)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 非晶質ナノシリカ / アレルギー / 自己免疫疾患 / アジュバント / 経口免疫寛容

Outline of Final Research Achievements

To investigate the effect of amorphous nanoparticles (AN) on allergic and autoimmune diseases, the nanoparticles were s.c. injected with the antigen ovalbumin (OVA). The results showed that OVA-specific immune responses including Th1, Th2 and Th17 were facilitated by AN. When AN was orally given with OVA before immunization with OVA, induction of OVA-specific oral tolerance was blocked. The blockade of the oral tolerance by AN was associated with the blockade of the suppression of production of Th1, Th2, and Th17 cytokines. Therefore, there is a possibility that the exposure to AN might induce or exacerbate allergic and autoimmune diseases.

Free Research Field

免疫毒性学