Precision medicine for molecular-targeted drugs using pharmacokinetics and metabolomics

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460185
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Tottori University
• Principal Investigator: Shimada Miki 鳥取大学, 医学部附属病院, 教授 (10196488)
• Co-Investigator(Kenkyū-buntansha): MANO NARIYASU 東北大学病院, 教授 (50323035)
• Co-Investigator(Renkei-kenkyūsha): MAEKAWA MASAMITSU 東北大学病院, 助教 (70572882)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 分子標的薬 / 副作用発現 / 薬物動態学パラメーター / 治療継続 / メタボロミクス

Outline of Final Research Achievements

To establish the precision medicine for molecular-targeted drugs, we have performed the study on the pharmacokinetics and the pharmacodynamics in this study.Our data obtained the monitoring the blood concentration of drug and its major metabolite in patients suggests that pharmacokinetic parameters of molecular-targeted drugs are predictive markers for therapeutic and adverse effects. Prelinarly, we have performed proteome analysis on the blood of patients prior/after taking molecular-targeted drugs. Between prior/after taking molecular-targeted drugs, we observed the difference of several endogenous compounds related to glycolysis/gluconeogenesis, TCA cycle, or citric acid cycle.

Free Research Field

医療薬学・薬物動態学