2015 Fiscal Year Final Research Report
Drug oxygenations and interactions mediated by polymorphic flavin-containing monooxygenases
| Project/Area Number |
25460198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Hiroshi 昭和薬科大学, 薬学部, 教授 (30191274)
MURAYAMA Norie 昭和薬科大学, 薬学部, 講師 (90219949)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | フラビン含有酸素添加酵素3 / FMO3 / 薬物代謝酵素 / 相互作用 |
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| Outline of Final Research Achievements |
The flavin-containing monooxygenase 3 (FMO3) catalyzes the oxygenation of N- and S- containing medicines and xenobiotic substances. From viewpoint of growing interest in drug interactions mediated by polymorphic FMO3, benzydamine N-oxygenation and sulindac sulfide S-oxygenation by human liver microsomal FMO3 were investigated as model reactions. Genetic polymorphisms in the human FMO3 gene might lead to some changes of enzyme activities and drug-drug interactions for N- or S-oxygenations of endogenous and xenobiotic substances including medicines. Since even the most common p.[(Glu158Lys; Glu308Gly)] variant FMO3 protein could result in stronger inhibition potential, genetic polymorphism of human FMO3 gene might lead to unexpected drug interactions via modulation of FMO3 catalytic efficiency.
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| Free Research Field |
薬物代謝
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