Possibility of drug interaction in the brain caused by changes in drug metabolism

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460200
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Meijo University
• Principal Investigator: Katoh Miki 名城大学, 薬学部, 准教授 (70345594)
• Co-Investigator(Kenkyū-buntansha): NADAI Masayuki 名城大学, 薬学部, 教授 (00295544)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 薬物代謝 / グルクロン酸抱合 / UGT / 脳 / 酵素誘導

Outline of Final Research Achievements

The purpose of this study was to clarify drug metabolism systems in the brain and the changes in these systems caused by xenobiotics. Drug-metabolizing enzymes were expressed in the rat brain, and their expression was induced by treatment with phenytoin or phenobarbital, which are anti-epileptic agents. Intraperitoneal phenobarbital treatment induced the production of reactive oxygen species that consequently caused the expression of drug-metabolizing enzymes. These changes in expression could affect pharmacological effects of drugs and physiological function of the brain, because of alterations in the concentrations of the drugs and endogenous compounds in the brain.

Free Research Field

薬物動態学