2015 Fiscal Year Final Research Report
Study on the nasal delivery route for the medical treatment for the cervical lymph node disease
| Project/Area Number |
25460201
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Shujitsu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKANE TOSHIYASU 京都薬科大学, 准教授 (50215638)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 経鼻吸収 / 頸部リンパ節 / リンパ節転移 / 鼻腔内投与 |
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| Outline of Final Research Achievements |
The cervical lymph node (CLN) receives the metastasis of the cancer and the inflammation by bacterial or virus infection arising in the head, nose, ear and throat. Our previous investigations suggested that nasal administration to rats enable the direct delivery of some model drugs to CLN. In this study, we investigated the direct transport of some additional model drugs to CLN through the nasal mucosa of mice in order to clarify the physicochemical property of drug suitable for the direct transport to CLN, and the inhibitory effect of the antitumor drug applied nasally on the cancer metastasis to the CLN using an orthotropic implantation mice model.
Intranasal administration is useful for the efficient delivery of drugs such as MTX to the CLN. MTX concentrations after nasal administration were increased in a dose-dependent manner. These findings suggest the feasibility of the effective therapy for the CLN metastasis by nasal administration of antitumor drugs.
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| Free Research Field |
医療系薬学
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