2015 Fiscal Year Final Research Report
Evaluation of cardiac energy-getting system by use of radiopharmaceuticals.
| Project/Area Number |
25460205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HARIMA Meirei 新潟薬科大学, 薬学部, 助手 (20333536)
IZUMIKAWA Takuji 新潟大学, 研究推進機構, 准教授 (60282985)
GOTO Jun 新潟大学, 研究推進機構, 助教 (90370395)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 心臓集積性標識薬剤 / 心臓エネルギー獲得機能 / 心機能評価 / 脂肪酸代謝機能 / 糖代謝機能 / 心不全疾患 / 心機能改善薬 / 糖尿病疾患 |
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| Outline of Final Research Achievements |
We invesitigated the change of the heart energy-getting system on the various heart conditions using the treated animals and heart-accumulated radiopharmaceuticals. In this study, we used three kinds of the treated animals described just below ; rats with chronic heart failure (CHF group), CHF group + heart-function improved agents (agent administration group) and mice with diabetes mellitus (DM group) and used the following three studies ; heart uptake study, fatty acid metabolic study, heart imaging study.
In the study using CHF group, it has been shown that the heart energy-getting system with CHF is shifted from fatty acid use to sugar use. In the study using agent (PV) administration group, it has been shown that the heart-function recovery by PV is caused by the increase of the fatty acid metabolic function. In the study using DM group, it has been shown that with increasing damage by DM, the fatty acid uptake in the heart decreases, and the sugar uptake increases.
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| Free Research Field |
医療系薬学、化学系薬学、放射性医薬品
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