2015 Fiscal Year Final Research Report
Role of Notch Singnaling in the progress of glomerulonephritis
| Project/Area Number |
25460216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Chubu University (2014-2015)
University of Shizuoka (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 腎炎 / Notch / 酸化ストレス |
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| Outline of Final Research Achievements |
The number of patients of artificial dialysis has been increasing these days. It is desired that the reduction of new end-stage renal disease in which dialysis is required in terms of both national medical expense and quality of patient’s life. Mesangial proliferative glomerulonephritis is the largest primary disease after diabetic nephropathy. In this study, we have found that transient expression of Notch1 receptor in a rat model of mesangial proliferative glomerulonephritis, suggesting that Notch signaling may be important in the progress of this disease. We have also found that a certain type of hydroxycarbazole have antioxidant capacity and may affect Notch signaling through the crosstalk of intracellular signaling.
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| Free Research Field |
医療薬学
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