2015 Fiscal Year Final Research Report
Development for new targets of anti-depressants using biological clock-system
| Project/Area Number |
25460221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | うつ病 / 生体リズム / 時計遺伝子 / 薬物有害反応 |
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| Outline of Final Research Achievements |
In this study, forced swimming test was performed in mice administered with interferon-alpha, mefloquine, and topiramate which are reported to induce a depressive disorder in clinical situation. Interferon-alpha significantly increased the immobility-time of mice, while mefloquine, and topiramate significantly decreased the time. Behavioral alterations in the forced swimming test were different by drugs used in the present study. Next, expression patterns of clock genes in the brain of mice administered with these drugs. All drugs decreased Per3 mRNA expression levels in the hippocampus, which resulted in the dampening of rhythm amplitude in mRNA expression.
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| Free Research Field |
医歯薬学
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